Massive Medical Breakthrough Could Save Millions of Lives

artificial heart

Heart disease is the world’s biggest killer, and around one in five people in developed countries will suffer heart failure in their lifetime. In the worst cases, the only treatment is a transplant. But with more hearts failing than being donated, patients can spend years on a waiting list.

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Artificial heart could save millions of lives

To help people awaiting a transplant, French company Carmat has developed a “total artificial heart” — a device to replace the whole heart until a donor can be found. Similar in shape to a human heart and weighing 4 kilograms, it is powered by two battery packs that provide around four hours of charge before the device needs to be connected to a mains power supply.

Sensors detect blood pressure and in response, an algorithm controls the blood flow in real time. “It works like a human heart so if the patient walks, the blood flow increases and if the patient is at rest, the blood flow is stable and low,” Carmat CEO Stéphane Piat tells CNN Business. The parts in contact with the patient’s blood are made from material that’s compatible with the human body, to reduce the risk of adverse reactions. Once surgically implanted, the device requires no maintenance, says Piat.

Nineteen patients have so far received the device in trials and in December, the company received a CE marking, allowing Carmat to sell the product in the European Union. Last month, it received authorization to start a feasibility study to gain approval from the US Food and Drug Administration.

artificial heart

Medical innovation could extend human life

Carmat hopes to start selling its artificial heart in Germany by the end of June. By the end of the year, Piat aims for Carmat to have made 20 hearts, which will be sold to hospitals for over €160,000 each ($190,000). While its suitable for most men, the current design is too big for most women.

Carmat was established in 2008 but French surgeon Alain Carpentier started developing its artificial heart 25 years ago. The company now has around 190 employees and has received more than €250 million ($300 million) in funding.
Martin Cowie, a professor of cardiology at Imperial College London, says researchers have been trying for decades to create a mechanical pump that can completely replace a heart. He says past attempts frequently caused strokes, blood clots, and infections, but the materials used by Carmat are a step in the right direction.

He adds that the design is an interesting concept. “Time will tell … but I like their ideas,” Carmat said.

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